Lowe ran the UK for a while in his time at the vendor before stepping up to the Northern European role a couple of years ago but will leave at the end of the month.
The UK managing director Terry Greer-King will continue to run things unchanged reporting into Bruno Darmon, vice president of European sales.
Greer-King stepped into the UK management role a year ago and has been actively trying to encourage resellers to take more of the vendor's product range.
In a statement Check Point said it wished Lowe "all the best for the future".
Lowe appears to be destined to reemerge quickly in the security industry in a senior position at Cyber Ark but was unavailable to confirm this at time of writing.